LL-37 and Citrullinated LL-37 Modulate Immune Responses in Inflammation
Study reveals how LL-37 cathelicidin and its citrullinated form differentially modulate IL-17-mediated immune responses, with implications for autoimmune and inflammatory diseases.
Quick Facts
What This Study Found
Study reveals how LL-37 cathelicidin and its citrullinated form differentially modulate IL-17-mediated immune responses, with implications for autoimmune and inflammatory diseases.
Key Numbers
Study tested LL-37 and citrullinated-LL-37 effects on multiple IL-17A/F-induced inflammatory mediators, with selective Lipocalin-2 suppression identified.
How They Did This
In publication.
Why This Research Matters
Relevant to peptide therapeutics.
The Bigger Picture
Advances peptide therapeutic knowledge.
What This Study Doesn't Tell Us
In publication.
Questions This Raises
- ?Long-term implications?
- ?Comparison to evidence?
- ?Next research?
Trust & Context
- Key Stat:
- Key finding Study reveals how LL-37 cathelicidin and its citrullinated form differentially modulate IL-17-mediat
- Evidence Grade:
- Based on study design.
- Study Age:
- Published in 2025.
- Original Title:
- LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells.
- Published In:
- Journal of inflammation (London, England), 22(1), 20 (2025)
- Authors:
- Altieri, Anthony, Lloyd, Dylan, Ramotar, Padmanie, van der Does, Anne M, Hemshekhar, Mahadevappa, Mookherjee, Neeloffer
- Database ID:
- RPEP-09911
Evidence Hierarchy
Frequently Asked Questions
What does this mean?
Study reveals how LL-37 cathelicidin and its citrullinated form differentially modulate IL-17-mediated immune responses, with implications for autoimmune and inflammatory diseases.
How reliable?
Consult publication.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-09911APA
Altieri, Anthony; Lloyd, Dylan; Ramotar, Padmanie; van der Does, Anne M; Hemshekhar, Mahadevappa; Mookherjee, Neeloffer. (2025). LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells.. Journal of inflammation (London, England), 22(1), 20. https://doi.org/10.1186/s12950-025-00446-w
MLA
Altieri, Anthony, et al. "LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells.." Journal of inflammation (London, 2025. https://doi.org/10.1186/s12950-025-00446-w
RethinkPeptides
RethinkPeptides Research Database. "LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated res..." RPEP-09911. Retrieved from https://rethinkpeptides.com/research/altieri-2025-ll37-and-citrullinatedll37-modulate
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.