Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.
Quick Facts
What This Study Found
The patient's macrophages showed significantly reduced cathelicidin production, impairing their ability to combat M. tuberculosis.
Key Numbers
How They Did This
The study involved analyzing macrophages from a patient with hereditary vitamin D-resistant rickets to assess cathelicidin production.
Why This Research Matters
Understanding how vitamin D influences immune responses can lead to better strategies for preventing and treating tuberculosis, especially in vulnerable populations.
What This Study Doesn't Tell Us
The findings are based on a single case study, limiting the generalizability of the results.
Trust & Context
- Original Title:
- Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.
- Published In:
- Frontiers in immunology, 13, 1038960 (2022)
- Authors:
- Al-Jaberi, Fatima A H, Crone, Cornelia Geisler, Lindenstrøm, Thomas, Arildsen, Nicolai Skovbjerg, Lindeløv, Emilia Sæderup, Aagaard, Louise, Gravesen, Eva, Mortensen, Rasmus, Andersen, Aase Bengaard, Olgaard, Klaus, Hjaltelin, Jessica Xin, Brunak, Søren, Bonefeld, Charlotte Menné, Kongsbak-Wismann, Martin, Geisler, Carsten
- Database ID:
- RPEP-05971
Evidence Hierarchy
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-05971APA
Al-Jaberi, Fatima A H; Crone, Cornelia Geisler; Lindenstrøm, Thomas; Arildsen, Nicolai Skovbjerg; Lindeløv, Emilia Sæderup; Aagaard, Louise; Gravesen, Eva; Mortensen, Rasmus; Andersen, Aase Bengaard; Olgaard, Klaus; Hjaltelin, Jessica Xin; Brunak, Søren; Bonefeld, Charlotte Menné; Kongsbak-Wismann, Martin; Geisler, Carsten. (2022). Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.. Frontiers in immunology, 13, 1038960. https://doi.org/10.3389/fimmu.2022.1038960
MLA
Al-Jaberi, Fatima A H, et al. "Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.." Frontiers in immunology, 2022. https://doi.org/10.3389/fimmu.2022.1038960
RethinkPeptides
RethinkPeptides Research Database. "Reduced vitamin D-induced cathelicidin production and killin..." RPEP-05971. Retrieved from https://rethinkpeptides.com/research/al-jaberi-2022-reduced-vitamin-dinduced-cathelicidin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.