This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
The patient's macrophages showed significantly reduced cathelicidin production, impairing their ability to combat M. tuberculosis.
Why it matters
Understanding how vitamin D influences immune responses can lead to better strategies for preventing and treating tuberculosis, especially in vulnerable populations.
How the study worked
The study involved analyzing macrophages from a patient with hereditary vitamin D-resistant rickets to assess cathelicidin production.
What this study cannot tell us
The findings are based on a single case study, limiting the generalizability of the results.
Read the original research
Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.
Frontiers in immunology, 13, 1038960
Citation
Al-Jaberi, Fatima A H; Crone, Cornelia Geisler; Lindenstrøm, Thomas; Arildsen, Nicolai Skovbjerg; Lindeløv, Emilia Sæderup; Aagaard, Louise; Gravesen, Eva; Mortensen, Rasmus; Andersen, Aase Bengaard; Olgaard, Klaus; Hjaltelin, Jessica Xin; Brunak, Søren; Bonefeld, Charlotte Menné; Kongsbak-Wismann, Martin; Geisler, Carsten. (2022). Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional vitamin D receptor: A case report.. Frontiers in immunology, 13, 1038960. https://doi.org/10.3389/fimmu.2022.1038960