Ghrelin's octanoyl modification by GOAT enzyme determines its metabolic activity, with acylation status differentially regulating GH release, appetite, and glucose metabolism — acylation as a therapeutic control point.
Key findingGhrelin's octanoyl modification by GOAT enzyme determines its metabolic activity, with acylation status differentially regulating GH release, appetite
What the researchers found
Ghrelin's octanoyl modification by GOAT enzyme determines its metabolic activity, with acylation status differentially regulating GH release, appetite, and glucose metabolism — acylation as a therapeutic control point.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2011.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin acylation and metabolic control.
Peptides, 32(11), 2301-8
Citation
Al Massadi, O; Tschöp, M H; Tong, J. (2011). Ghrelin acylation and metabolic control.. Peptides, 32(11), 2301-8. https://doi.org/10.1016/j.peptides.2011.08.020