Chicken By-Product Protein Yields Potent Blood Pressure-Lowering Peptides After Separation
Fractionated chicken by-product protein hydrolysates showed enhanced antihypertensive activity, with separated peptide fractions more potent than the original mixture for ACE inhibition.
Quick Facts
What This Study Found
Fractionated chicken by-product hydrolysates showed enhanced ACE-inhibitory activity compared to the unfractionated mixture, identifying specific peptide fractions with potent antihypertensive properties.
Key Numbers
Peptide separation was based on charge and molecular weight using EDUF. Specific ACE-inhibitory activity measurements were compared across fractions.
How They Did This
Enzymatic hydrolysis of chicken by-product proteins. Separation of hydrolysate into fractions. Assessment of ACE-inhibitory activity and antihypertensive peptide characterization.
Why This Research Matters
Converting food waste into health-promoting peptides addresses both sustainability and health goals. Chicken processing by-products could become a source of affordable blood pressure-lowering supplements.
The Bigger Picture
Upcycling food industry waste into bioactive peptides is a growing field that addresses both environmental sustainability and public health. Chicken by-products join dairy, fish, and plant proteins as sources of heart-healthy peptides.
What This Study Doesn't Tell Us
In vitro ACE inhibition study. In vivo blood pressure effects in animals or humans not tested. Peptide stability through human digestion needs evaluation.
Questions This Raises
- ?Would consuming these peptide fractions lower blood pressure in human studies?
- ?Can the separation process be scaled for commercial production?
- ?How do chicken-derived antihypertensive peptides compare to dairy-derived alternatives?
Trust & Context
- Key Stat:
- Waste to medicine Chicken processing by-products yielded potent ACE-inhibitory peptides after enzymatic digestion and fractionation
- Evidence Grade:
- Preliminary evidence: in vitro ACE inhibition study with peptide fractionation. No in vivo blood pressure data.
- Study Age:
- Published in 2025. Advances food waste upcycling into bioactive peptide products.
- Original Title:
- Enhanced antihypertensive chicken by-product hydrolysate fraction after its separation by electrodialysis with ultrafiltration membrane (EDUF).
- Published In:
- Food research international (Ottawa, Ont.), 202, 115595 (2025)
- Authors:
- Adaile-Pérez, Vianey Monsserrat, Thibodeau, Jacinthe, Ortiz-Basurto, Rosa Isela, de Lourdes García-Magaña, María, Bazinet, Laurent
- Database ID:
- RPEP-09766
Evidence Hierarchy
Frequently Asked Questions
Can chicken by-products lower blood pressure?
When chicken processing by-product proteins are enzymatically digested and separated, specific peptide fractions show potent ACE-inhibitory activity — the same mechanism as blood pressure medications like lisinopril. Human studies are needed to confirm the effect.
How is food waste turned into health products?
Enzymes break down waste proteins into small peptides, some of which have biological activity. Separation techniques then isolate the most active peptide fractions. This upcycling approach creates value from materials that would otherwise be discarded.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-09766APA
Adaile-Pérez, Vianey Monsserrat; Thibodeau, Jacinthe; Ortiz-Basurto, Rosa Isela; de Lourdes García-Magaña, María; Bazinet, Laurent. (2025). Enhanced antihypertensive chicken by-product hydrolysate fraction after its separation by electrodialysis with ultrafiltration membrane (EDUF).. Food research international (Ottawa, Ont.), 202, 115595. https://doi.org/10.1016/j.foodres.2024.115595
MLA
Adaile-Pérez, Vianey Monsserrat, et al. "Enhanced antihypertensive chicken by-product hydrolysate fraction after its separation by electrodialysis with ultrafiltration membrane (EDUF).." Food research international (Ottawa, 2025. https://doi.org/10.1016/j.foodres.2024.115595
RethinkPeptides
RethinkPeptides Research Database. "Enhanced antihypertensive chicken by-product hydrolysate fra..." RPEP-09766. Retrieved from https://rethinkpeptides.com/research/adaile-perez-2025-enhanced-antihypertensive-chicken-byproduct
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.