VIP deficiency impaired T-cell infiltration into brain tissue and paradoxically increased resistance to EAE (MS model), revealing VIP's complex role in both enabling and modulating brain autoimmune inflammation.
Key findingVIP deficiency impaired T-cell infiltration into brain tissue and paradoxically increased resistance to EAE (MS model), revealing VIP's complex role i
What the researchers found
VIP deficiency impaired T-cell infiltration into brain tissue and paradoxically increased resistance to EAE (MS model), revealing VIP's complex role in both enabling and modulating brain autoimmune inflammation.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2010.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19555-60
Citation
Abad, Catalina; Tan, Yossan-Var; Lopez, Robert; Nobuta, Hiroko; Dong, Hongmei; Phan, Phu; Feng, Ji-Ming; Campagnoni, Anthony T; Waschek, James A. (2010). Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.. Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19555-60. https://doi.org/10.1073/pnas.1007622107