Peptide Therapies for IBS

2 articles in this topic.

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Plecanatide: The Uroguanylin Analog for IBS-C

Plecanatide (Trulance) is a 16-amino acid uroguanylin analog FDA-approved for IBS-C and chronic constipation. Phase 3 data, mechanism, and how it compares.

26 min read|Mar 20, 2026

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Peptide Therapies for IBS

Gut Peptide Dysregulation in IBS

IBS patients show altered levels of serotonin, PYY, CCK, VIP, and GLP-1 in gut tissue and blood. Here is what the peptide data reveals about this disorder.

13 min read|Mar 22, 2026