Melanocortin Immune Regulation

3 articles in this topic.

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Melanocortin Peptides and Immune Regulation

Alpha-MSH and related melanocortin peptides regulate inflammation through MC1R, MC3R, and MC5R. Review of immune mechanisms, disease applications, and drugs.

18 min read|Mar 20, 2026

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Melanocortin Immune Regulation

KPV and NF-kB: How a Tripeptide Blocks Inflammation

KPV, the C-terminal tripeptide of alpha-MSH, inhibits NF-kB nuclear translocation and reduces pro-inflammatory cytokines. Here is the molecular mechanism.

13 min read|Mar 22, 2026

Melanocortin Immune Regulation

KPV: The Three-Amino-Acid Anti-Inflammatory

KPV, a tripeptide from alpha-MSH, inhibits NF-kB activation and reduces inflammation through PepT1 transport. Review of mechanism and preclinical evidence.

12 min read|Mar 22, 2026